Mechanisms of protein aggregation

From the Pappu lab: Research in the Pappu lab focuses on mechanisms of protein aggregation. A combination of polymer theory, novel simulations, and experiments are being used. The image shows the result of a first principles simulation of the self-association two intrinsically disordered polyglutamine molecules. Predictions made from analyzing these types of data are yielding insights into the molecular basis of Huntington's disease, which is associated with mutations that lead to polyglutamine expansions. For more details, please visit the Pappu lab at http://lima.wustl.edu.

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